Background. Acute generalized exanthematous pustulosis (AGEP) is an acute pustular eruption characterized by widespread\nnonfollicular sterile pustules.Theaimof this study is to characterize the etiology, clinical features, laboratory findings, management,\nand outcome of patients with AGEP in Asians. Patient/Methods. A retrospective analysis was performed on patient who presented\nwith AGEP between August 2008 and November 2012 in a tertiary center inThailand. Results. Nineteen patients with AGEP were\nincluded. AGEP was generally distributed in seventeen patients (89.5%) and localized in two (10.5%). Fever and neutrophilia\noccurred in 52.6% and 68.4%, respectively. Hepatitis was found up to 26.3%. The most common etiology was drugs (94.7%),\ncomprising of antibiotics (73.6%), proton pump inhibitors (10.5%), nonsteroidal anti-inflammatory drugs (5.3%), and herbal\nmedicine (5.3%). Beta-lactams were the most common causal drug, particularly carbapenems and cephalosporins. This is the first\nreport of Andrographis paniculata as an offending agent for AGEP. We found no differences between various treatment regimens\n(topical corticosteroid, systemic corticosteroid, and supportive treatment) regarding the time from drug cessation to pustules\nresolution (
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